What is Prolozone and how does it work?
Prolozone is an injection therapy that combines a local anaesthetic, nutrients, and a measured oxygen-ozone mixture, delivered into a painful joint, ligament, or tendon. The intent is to reduce inflammation and improve the local oxygen environment so the tissue is better able to repair itself. It is normally given as a series of injections rather than a single treatment. It is not FDA-approved to treat, cure, or prevent any disease, and its published evidence base is thinner than that of PRP.
What is actually in the injection
A typical Prolozone injection includes a local anaesthetic for comfort, a nutrient component such as B vitamins and minerals, and an oxygen-ozone gas mixture at a controlled concentration. The proportions and the exact formulation vary by provider and by treatment site.
Anyone offering it should be able to tell you specifically what is in the injection you are receiving and at what ozone concentration.
The proposed mechanism
Chronically painful ligaments and joints often have poor circulation and low local oxygen availability, which is one reason they heal slowly. The rationale behind Prolozone is that transiently raising oxygen availability in that tissue, alongside reducing inflammation, creates conditions more favourable to repair.
This is a plausible mechanism, and patients frequently report benefit, but it is important to be clear that mechanism is not the same as proof of effect for a given condition.
How it is typically delivered
Sessions are usually spaced one to two weeks apart across a series, with the number depending on how long the problem has been present and which structure is being treated. Some improvement is often noticed after the first one or two sessions, with the fuller effect building across the series.
The area is numbed first, and most patients describe pressure and a brief stinging rather than sharp pain.
More about Prolozone Injection Therapy
Find out if Prolozone fits your problem
Book a consultation with our Folsom naturopathic team to talk through your condition and whether a Prolozone series is worth considering.
Bring recent lab work if you have it — we’ll review it with you.
Medical disclaimer: The information on this page is for general education and is not medical advice, diagnosis, or treatment. Prolozone is not FDA-approved to cure, treat, or prevent any disease, and evidence for its use is still developing. This page does not claim or imply any outcome. Individual results vary and no specific outcome is guaranteed. Whether Prolozone is appropriate for you can only be determined after an in-person evaluation with a licensed provider.